Playing Destroy All Humans! 2 - Reprobed on macOS
Destroy All Humans! 2 - Reprobed plays excellent on macOS. It's been tested using the methods below:
- CrossOver is the most popular way to play Windows games on macOS.
Check game test reports below for performance, tips, and mac hardware tested.
About Destroy All Humans! 2 - Reprobed

Crypto is back with a license to probe. The alien invader returns, groovier than ever. Experience the swinging ‘60s in all its chemical-induced glory and take revenge on the KGB for blowing up your mothership. You’ll have to form alliances with members of the very species you came to enslave.

Key Features:
- Show those hippies who's boss using classic weapons and new technology like the Meteor Shower
- Explore 1960’s Mother Earth and unload your trusty saucer all over her fictional cities
- Defend a much larger, much more open world from those who seek to undermine your mission
- Hoover up humans from different countries and grind them up into DNA cocktails to upgrade your skills
- Invite a friend over for a twosome and enjoy the full story in local 2-player split screen co-op

macOS Game Tests
Destroy All Humans! 2 - Reprobed tested on macOS.
Destroy All Humans! 2 - Reprobed is not natively supported on macOS. See below for potential ways you can play it that have been tested.
Excellent 1440p < 1 Hour Played 45 FPS
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Hardware
Mac mini M4
Sequoia, 24GB Memory
10-Core CPU, 10-Core GPU
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Method
v25.0.1
- Launcher Steam
- Graphics Preset Custom
Additional Information
I had all graphic settings on Normal except Foliage and Antialiasing on Low. I also had FSR on Quality, though I'm not sure if that works or not.